Common Genetic Factors Found in 5 Mental Disorders

Major Mental Disorders

Major mental disorders traditionally thought to be distinct share certain genetic glitches, according to a new study. The finding may point to better ways to diagnose and treat these conditions.

Scientists have long recognized that many psychiatric disorders tend to run in families, suggesting potential genetic roots. Such disorders include autism, attention deficit hyperactivity disorder (ADHD), bipolar disorder, major

depression and schizophrenia. Symptoms can overlap and so distinguishing among these 5 major psychiatric syndromes can be difficult. Their shared symptoms suggest they may also share similarities at the biological level. In fact, recent studies have turned up limited evidence of shared genetic risk factors, such as for schizophrenia and bipolar disorder, autism and schizophrenia, and depression and bipolar disorder.

Common Genetic Factors Found in 5 Mental Disorders


 Get The Latest By Email

Weekly Magazine Daily Inspiration

To take a broader look, an international research consortium conducted an analysis that incorporated data from genome-wide association studies (GWAS) of the 5 major disorders. This type of study involves scanning through thousands of genetic markers in search of tiny variations that appear more often in people who have a particular condition than in those who don't. The research received primary funding from NIH’s National Institute of Mental Health (NIMH), along with other NIH components.

on February 28, 2013, the scientists screened for evidence of illness-associated genetic variation among over 33,000 patients. All had been diagnosed with at least 1 of the 5 disorders. A comparison group included about 28,000 people who had no major psychiatric diagnosis.

The analysis revealed variations significantly associated with all 5 disorders. These included variations in 2 genes that code for the cellular machinery that helps regulate the flow of calcium into neurons. had previously been linked to bipolar disorder, schizophrenia and major depression. is known to affect brain circuitry involved in emotion, thinking, attention and memory—functions that can be disrupted in mental illnesses. was also linked to the 5 disorders.

In addition, the researchers discovered illness-linked variation for all 5 disorders in certain regions of chromosomes 3 and 10. Each of these sites spans several genes, and causal factors haven’t yet been pinpointed. The suspect region along chromosome 3 had the strongest links to the disorders. This region also harbors certain variations previously linked to bipolar disorder and schizophrenia.

Although statistically significant, each of these genetic associations individually can account for only a small amount of risk for mental illness,” says study co-author Dr. Jordan Smoller of Massachusetts General Hospital. Because of this, the variations couldn’t yet be used to predict or diagnose specific conditions. But these results may help researchers move closer to making more accurate diagnoses. They may also help lead to a better understanding of the factors that cause these major mental disorders.

Article Source: NIH Research Matters

AVAILABLE LANGUAGES

English Afrikaans Arabic Chinese (Simplified) Chinese (Traditional) Danish Dutch Filipino Finnish French German Greek Hebrew Hindi Hungarian Indonesian Italian Japanese Korean Malay Norwegian Persian Polish Portuguese Romanian Russian Spanish Swahili Swedish Thai Turkish Ukrainian Urdu Vietnamese

follow InnerSelf on

facebook icontwitter iconyoutube iconinstagram iconpintrest iconrss icon

 Get The Latest By Email

Weekly Magazine Daily Inspiration

Thursday, 15 April 2021 13:22

Skin brushing is a highly effective technique for cleansing the lymphatic system. Topics covered in this article: Benefits of Skin Brushing; What type of skin brush is the best to use; How to Brush...

Wednesday, 21 April 2021 07:23

Whether it’s your arthritic relative who knows rain is on the way when their knees ache or your lifelong pal who gets a headache when a storm is approaching, we all know somebody who claims they...

Saturday, 08 May 2021 08:43

Humanity has always had a rocky relationship with wasps. They are one of those insects that we love to hate. We value bees (which also sting) because they pollinate our crops and make honey

Friday, 14 May 2021 16:24

The chakras set the frequencies that give rise to every aspect of the human experience. The foods we eat have consciousness and provide an energetic blueprint that stabilizes and entrains...

Friday, 21 May 2021 10:09

The humble potato has been given a bad rap. What was once a cheap staple of many countries’ diets has instead been branded in recent years an “unhealthy” food best avoided.

Wednesday, 19 May 2021 08:07

For many people, the thing they’ve missed most during the pandemic is being able to hug loved ones. Indeed, it wasn’t until we lost our ability to hug friends and family did many realise just how...

New Attitudes - New Possibilities

InnerSelf.comClimateImpactNews.com | InnerPower.net
MightyNatural.com | WholisticPolitics.com | InnerSelf Market
Copyright ©1985 - 2021 InnerSelf Publications. All Rights Reserved.